Anxiety disorders are among the most common psychiatric conditions affecting children and adolescents. While antidepressants are frequently used to treat youth with anxiety disorders, sometimes, antidepressants may be poorly tolerated in children who are at high risk of developing bipolar disorder.
The study published in the Journal of Child and Adolescent Psychopharmacology, looked at brain imaging in youth before and after mindfulness-based therapy and saw changes in brain regions that control emotional processing.
In a small group of youth identified with anxiety disorders (generalised, social and/or separation anxiety) and who have a parent with bipolar disorder, researchers evaluated the neurophysiology of mindfulness-based cognitive therapy in children who are considered at-risk for developing bipolar disorder.
“Our preliminary observation that the mindfulness therapy increases activity in the part of the brain known as the cingulate, which processes cognitive and emotional information, is noteworthy,” says Dr Jeffrey Strawn, associate professor in the Department of Psychiatry and Behavioural Neuroscience.
“This study, taken together with previous research, raises the possibility that treatment-related increases in brain activity [of the anterior cingulate cortex] during emotional processing may improve emotional processing in anxious youth who are at risk for developing bipolar disorder.”
The study’s findings in regard to increases in activity in the part of the brain known as the insula, the part of the brain responsible for monitoring and responding to the physiological condition of the body, are of high interest, Strawn adds.
In this pilot trial, nine participants aged 9 to 16 years, underwent functional magnetic resonance imaging (fMRI) while performing continuous performance tasks with emotional and neutral distractors prior to and following 12 weeks of mindful-based cognitive therapy.
“Mindfulness-based therapeutic interventions promote the use of meditative practices to increase present-moment awareness of conscious thoughts, feelings and body sensations in an effort to manage negative experiences more effectively,” says Sian Cotton, PhD, an associate professor of family and community medicine at UC, director of the UC’s Center for Integrative Health and Wellness and a co-author on the study. “These integrative approaches expand traditional treatments and offer new strategies for coping with psychological distress.”
“Clinician-rated anxiety and youth-rated trait anxiety were significantly reduced following treatment; the increases in mindfulness were associated with decreases in anxiety. Increasingly, patients and families are asking for additional therapeutic options, in addition to traditional medication-based treatments, that have proven effectiveness for improved symptom reduction. Mindfulness-based therapies for mood disorders is one such example with promising evidence being studied and implemented at UC.”
“The path from an initial understanding of the effects of psychotherapy on brain activity to the identification of markers of treatment response is a challenging one, and will require additional studies of specific aspects of emotional processing circuits,” says Strawn.